More Study Details
The APOLLO Community Advisory Council (CAC), convened by the National Institutes of Health (NIH) & APOLLO Steering Committee, is working with the APOLLO Investigators. The CAC represents many facets of the transplant community including transplant recipients, kidney donors, individuals on dialysis and those with end-stage renal disease. Their primary role is to provide input and guidance to the APOLLO study on all matters, including recruitment, retention and return of results. CAC members participate in regular conference calls and in Steering Committee Meetings on the NIH campus and are represented on Steering Committee calls.
NIAID, NIDDK, NIMHD
- HLA Genotyping Labs - HLA Genotyping Labs located across the U.S. including Puerto Rico are collaborating with the National Institutes of Health (NIH) and the APOLLO study. HLA Genotyping Labs will receive APOLLO tubes of blood and urine from OPOs for deceased kidney donors. These centers routinely receive biosamples and extract DNA for clinical use. HLA Genotyping Labs will extract DNA from an APOLLO acid citrate dextrose (ACD) tube, separate serum from a red top tube and provide storage for DNA, serum and urine. They will ship these samples to the SDRC at regular, pre-specified intervals. An APOLLO/AOPO letter to HLA Genotyping Labs outlining their role in the study will be provided to each lab prior to initiation of recruitment.
- AOPO/OPOs - The Association of Organ Procurement Organizations (AOPO) and local Organ Procurement Organizations (OPOs) will assess whether the families of deceased donors agree that eligible organ donor's tissues and biosamples may be included in research studies. The OPO will follow its established protocol of authorizing organ donation and research from donor families. The OPO will also facilitate initial contact between APOLLO and organ donors (or their family decision maker).
- UNOS - The United Network for Organ Sharing (UNOS) will provide clinical data that arises from routine, standard-of-care and follow-up visits. The UNOS ID number will also be used to track APOLLO participants. The Statistical and Data Research Center (SDRC) will work closely with UNOS to identify electronic data needed and the most efficient mode to transfer data. The SDRC will complete all UNOS mandated confidentiality agreements pertaining to data transfer on behalf of APOLLO.
Publications (or Bibliography)
- Freedman BI, Moxey-Mims M. The APOL1 Long-Term Kidney Transplantation Outcomes Network-APOLLO. Clin J Am Soc Nephrol. 2018 Jun 7;13(6):940-942